Determine the role of intrinsic immune checkpoint signalling in the progression of pre-malignant Barret’s oesophagus to Oesophageal Adenocarcinoma Cancer: expanding the target cohort for immune checkpoint inhibition
Sam Cahill
Sam is MSc student appointed by the All-Ireland Cancer Research Network (AllCaN) Programme. Sam is working under the supervision of Prof. Joanne Lysaght and Dr. Aideen Ryan at Trinity College Dublin.
This project will investigate a preventative treatment approach to oesophageal cancer by further understanding how the cancer develops. Patients with an increased risk of developing Oesophageal cancer (Barrett’s Oesophagus) observe distinct changes to the cells of their oesophagus. This research will further understand how these cells become cancerous, and whether these cellular changes may be therapeutically targeted by existing drugs to prevent cancer from developing.
Back
Start year
2024
End year
2026
Principal Investigators
Prof. Joanne Lysaght, Dr. Aideen Ryan
Researcher
Sam Cahill
Institution
Trinity College Dublin
Grant Funding
All-Ireland Cancer Research Network (AllCaN) Programme
Linked Breakthrough Research Priorities
Increase research investment into poor prognosis cancers and currently incurable cancers prioritising lung, oesophageal, ovarian, pancreatic, brain, liver and stomach cancers.
Fund the discovery and development of new therapeutics, surgical approaches and technologies, including biological and immune approaches, to improve cancer treatment.
Fund research which aims to improve the effectiveness or specificity of current cancer therapies including investing in biomarkers discovery, nutrition and therapeutic delivery.
Contact