Investigation into the role of autophagy in differentiation in leukaemia
Ciara Ruth Gavin
Ciara Gavin received the Breakthrough Cancer Summer Scholarship, enabling her to conduct research under the supervision of Dr. Sharon McKenna & Dr. Tracey O’Donovan at University College Cork during the summer.
Arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA) are used in differentiation therapy for certain kinds of leukemia. For my summer project, I am working under Dr Tracey O’Donovan to learn more about how these compounds affect leukemia cells, with the hopes of using them to treat other kinds of leukemia in the future. Differentiation therapy is really effective, providing a long-term cure for 90% of patients, so being able to apply it to other kinds of leukemia could make a huge difference to people with the disease.
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Start year
2021
End year
2021
Principal Investigator
Dr. Sharon McKenna & Dr. Tracey O'Donovan
Researcher
Ciara Ruth Gavin
Institution
University College Cork
Grant Funding
Breakthrough Cancer Research Summer Scholarship
Linked Breakthrough Research Priorities
Fund the discovery and development of new therapeutics, surgical approaches and technologies, including biological and immune approaches, to improve cancer treatment.
Fund research which aims to improve the effectiveness or specificity of current cancer therapies including investing in biomarkers discovery, nutrition and therapeutic delivery.
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