Effect of a novel drug and electroporation on melanoma and intratumoural immune cells viability and function

Dr Liam Tremble

Dr Liam Tremble has been awarded his PhD from University College Cork.  Liam is continuing this work collaborative study between University College Cork and the Trinity Centre for Health Sciences in St James’ Hospital, Dublin investigating a novel drug in combination with electroporation as a treatment for melanoma.

Research Findings

Publications

Tremble LF, Moore AC, Forde PF. Melanoma-conditioned medium promotes cytotoxic immune responses by murine bone marrow-derived monocytes despite their expression of ‘M2’ markers. Cancer Immunol Immunother. 2019 Sep;68(9):1455-1465. doi: 10.1007/s00262-019-02381-1. Epub 2019 Aug 23. PMID: 31444606.

Tremble LF, Heffron CCBB, Forde PF. The effect of calcium electroporation on viability, phenotype and function of melanoma conditioned macrophages. Sci Rep. 2020 Nov 26;10(1):20645. doi: 10.1038/s41598-020-77743-2. PMID: 33244152; PMCID: PMC7691332.

Tremble LF, McCabe M, Walker SP, McCarthy S, Tynan RF, Beecher S, Werner R, Clover AJP, Power XDG, Forde PF, Heffron CCBB. Differential association of CD68⁺ and CD163⁺ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma. Br J Cancer. 2020 Nov;123(10):1553-1561. doi: 10.1038/s41416-020-01037-7. Epub 2020 Aug 26. PMID: 32843682; PMCID: PMC7653046.