Investigation of the role of cysteinyl leukotriene (CysLT) receptors in Uveal Melanoma

Kaelin Smith

Kaelin Smith is a research assistant joining the Ocular Pharmacology and Genetics Group at University College Dublin. He will join a Breakthrough Cancer Research-funded project that aims to investigate the role of cysteinyl leukotriene (CysLT) receptors in Uveal Melanoma and whether blocking these receptors with drugs can alter different cancer hallmarks.

Related References:

Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O’Connell F, Piulats JM, O’Neill V, Horgan N, Coupland SE, O’Sullivan J, Gallagher WM, Villanueva A, Kennedy BN. 1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model. Front Med (Lausanne). 2023 Jan 9;9:1036322. PMID: 36698840; PMCID: PMC9868667. doi: 10.3389/fmed.2022.1036322.

 

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Start year
2020
End year
2021
Principal Investigator
Prof. Breandan Kennedy
Researcher
Kaelin Smith
Institution
University College Dublin
Grant funding
Breakthrough Project Grant
Linked Breakthrough Research Priorities
1, 3, 4