Investigation of the role of cysteinyl leukotriene (CysLT) receptors in Uveal Melanoma

Kaelin Smith

Kaelin Smith is a research assistant joining the Ocular Pharmacology and Genetics Group at University College Dublin. He will join a Breakthrough Cancer Research-funded project that aims to investigate the role of cysteinyl leukotriene (CysLT) receptors in Uveal Melanoma and whether blocking these receptors with drugs can alter different cancer hallmarks.

Research Findings

Publications

Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O’Connell F, Piulats JM, O’Neill V, Horgan N, Coupland SE, O’Sullivan J, Gallagher WM, Villanueva A, Kennedy BN. 1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model. Front Med (Lausanne). 2023 Jan 9;9:1036322. PMID: 36698840; PMCID: PMC9868667. doi: 10.3389/fmed.2022.1036322.