Investigating the effect of calcium electroporation on the inflammatory microenvironment and crosstalk to immune cell activation across the Barrett's-dysplasia-adenocarcinoma disease sequence
Lorraine Smith
Lorraine Smith is the first PhD student appointed to the All-Ireland Cancer Research Network (AllCaN) Programme. Lorraine, working in the lab of Prof Jacintha O’Sullivan in the Trinity St James Cancer Institute will investigate a new treatment called electroporation which involves applying electrical pulses to cells, making them more responsive to therapies. This treatment is already in clinical trials for numerous cancers and early results are very positive. This project will investigate the science behind the treatment: how does it affect the cells treated and can it activate the immune system?
RESEARCH FINDINGS
Conferences Presentations
5th World Congress on Electroporation 2024, Rome, Italy. Title: “Electroporation treatment alters the inflammatory tissue microenvironment in the human inflammatory condition, Barrett’s Oesophagus”.
Awards
Travel grant from Doreen J. Putrah Cancer Research Foundation – $1,000 award to attend the 5th World Congress on Electroporation in Rome, Italy, September 2024.
Back
Start year
2023
End year
2027
Principal Investigator
Prof. Jacintha O'Sullivan
Researcher
Lorraine Smith
Institution
Trinity St James Cancer Institute
Grant Funding
All-Ireland Cancer Research Network (AllCaN) Programme
Linked Breakthrough Research Priorities
Increase research investment into poor prognosis cancers and currently incurable cancers prioritising lung, oesophageal, ovarian, pancreatic, brain, liver and stomach cancers.
Improve integration of cancer research into cancer care in Ireland and increase clinical capacity by prioritising funding for projects and programmes with significant clinical engagement.
Fund the discovery and development of new therapeutics, surgical approaches and technologies, including biological and immune approaches, to improve cancer treatment.
Contact